Nishiyama Akihiro, Shikata Chihiro, Kimura Nobuaki, Imanishi Akio, Hirai Noriyuki, Ohta Makoto, Takeda Nobuakira
Departments of Internal Medicine and.
Exp Clin Cardiol. 2005 Summer;10(2):108-10.
To examine risk factors for coronary artery sclerosis in patients with diabetes mellitus.
Patients with diabetes were divided into two groups based on whether their electrocardiogram (ECG) showed ischemic changes. In addition to traditional risk factors, other parameters (ie, serum levels of serotonin, homocysteine, thrombomodulin, plasminogen activator inhibitor-1, tissue plasminogen activator, vascular endothelial growth factor, intercellular adhesion molecule-1, vascular cell adhesion molecule-1 and endothelial-leukocyte adhesion molecule-1) were measured in both groups.
In the group with ischemic ECG changes (n=13), systolic blood pressure was significantly higher than in the group with no changes (n=18). There were no significant differences in the serum levels of other factors; however, body mass index, hemoglobin A1c, total cholesterol, low density lipoprotein cholesterol and triglyceride levels tended to be higher in the group with ischemic ECG changes.
Although the sample of patients was limited, these results suggest that strict control of traditional risk factors, especially high blood pressure, is important for preventing coronary artery sclerosis in patients with diabetes mellitus.
研究糖尿病患者冠状动脉硬化的危险因素。
根据心电图（ECG）是否显示缺血性改变，将糖尿病患者分为两组。除传统危险因素外，还对两组患者的其他参数（即血清5-羟色胺、同型半胱氨酸、血栓调节蛋白、纤溶酶原激活物抑制剂-1、组织纤溶酶原激活物、血管内皮生长因子、细胞间黏附分子-1、血管细胞黏附分子-1和内皮白细胞黏附分子-1水平）进行了检测。
心电图有缺血性改变的组（n = 13）收缩压显著高于无改变的组（n = 18）。其他因素的血清水平无显著差异；然而，心电图有缺血性改变的组体重指数、糖化血红蛋白、总胆固醇、低密度脂蛋白胆固醇和甘油三酯水平往往更高。
尽管患者样本有限，但这些结果表明，严格控制传统危险因素，尤其是高血压，对于预防糖尿病患者的冠状动脉硬化很重要。
