N-乙酰咪唑对牛乳腺组织中催产素结合的影响。

Effects of N-acetylimidazole on oxytocin binding in bovine mammary tissue.

作者信息

Zhao X, Gorewit R C, Currie W B

机构信息

Department of Animal Science, New York State College of Agricultural and Life Sciences, Cornell University, Ithaca 14853.

出版信息

J Recept Res. 1990;10(5-6):287-98. doi: 10.3109/10799899009064671.

DOI:10.3109/10799899009064671

PMID:1964176

Abstract

The effects of N-acetylimidazole on specific binding of oxytocin to microsomal fractions of bovine mammary gland were studied. N-acetylimidazole suppressed oxytocin binding, with time and concentration dependence. Decreased oxytocin binding activity appeared to be due to decreased affinity of the hormone for its receptor. Acetylation of oxytocin, rather than of oxytocin receptors, seemed to be responsible for the decreased binding.

摘要

研究了N-乙酰咪唑对牛乳腺微粒体部分中催产素特异性结合的影响。N-乙酰咪唑抑制催产素结合，具有时间和浓度依赖性。催产素结合活性降低似乎是由于该激素与其受体的亲和力降低所致。催产素的乙酰化而非催产素受体的乙酰化似乎是结合减少的原因。