Goodman J H, Gahbauer R A, Kanellitsas C, Clendenon N R, Laster B H, Fairchild R G
Department of Surgery, Ohio State University, Columbus.
Stereotact Funct Neurosurg. 1990;54-55:531-4. doi: 10.1159/000100268.
A technique to produce radiation enhancement during interstitial brain tumor irradiation by using a radiation sensitizer (iododeoxyuridine-IdUrd) and by stimulation of Auger electron cascades through absorption of low-energy photons in iodine is described. Clinical studies using iododeoxyuridine, 192Ir as a brachytherapy source, and external radiation have produced promising results. Substituting 145Sm for 192Ir in this protocol is planned to evaluate the enhanced dose resulting from photon activation therapy.
