Nanyang Technological University, Singapore.
Adv Drug Deliv Rev. 2009 Oct 5;61(12):1055-64. doi: 10.1016/j.addr.2009.07.009. Epub 2009 Jul 28.
The repairing process in the nervous system is complicated and brings great challenges to researchers. Tissue engineering scaffolds provide an alternative approach for neural regeneration. Sub-micron and nano-scale fibrous scaffolds which mimic the topography of natural extracellular matrix (ECM) can be potential scaffold candidates for neural tissue engineering. Two fiber-fabrication methods have been explored in the field of nerve regeneration: electrospinning and self-assembly. Electrospinning produces fibers with diameters ranging from several micrometers to hundreds of nanometers. The fibrous nerve conduits can be introduced at lesion sites by implantation. Self-assembly fibers have diameters of tens of nanometers and can be injected for central nervous system (CNS) injury repair. Both fibrous scaffolds would enhance neurite extension and axon regrowth. These functional nanofibrous scaffolds can serve as powerful tools for neural tissue engineering.
神经系统的修复过程较为复杂，给研究人员带来了巨大的挑战。组织工程支架为神经再生提供了一种替代方法。亚微米和纳米级纤维支架模仿天然细胞外基质（ECM）的拓扑结构，可以作为神经组织工程的潜在支架候选物。在神经再生领域已经探索了两种纤维制造方法：静电纺丝和自组装。静电纺丝产生的纤维直径范围从几微米到几百纳米。纤维状神经导管可以通过植入物引入病变部位。自组装纤维的直径为数十纳米，可以注射用于中枢神经系统（CNS）损伤修复。这两种纤维支架都可以促进神经突的延伸和轴突的再生。这些功能性纳米纤维支架可以作为神经组织工程的有力工具。
