Gallo Andrea, Degener Anna Marta, Pagliuca Giulio, Pierangeli Alessandra, Bizzoni Federica, Greco Antonio, de Vincentiis Marco
Department of Otorhinolaryngology, G. Ferreri, Sapienza University, Rome, Italy.
Otolaryngol Head Neck Surg. 2009 Aug;141(2):276-81. doi: 10.1016/j.otohns.2009.04.021.
To investigate the role of human papillomavirus (HPV) and adenovirus (AdV) infections in the oncogenesis of squamous cell carcinomas of the larynx and of laryngeal dysplasia.
Cross-sectional study with planned data collection.
Department of Otorhinolaryngology G. Ferreri and Department of Experimental Medicine and Pathology-Section of Virology, Sapienza University of Rome.
Biopsy samples were taken from 68 patients with benign and malignant lesions of the larynx. All tissue samples were analyzed by means of polymerase chain reaction with two groups of primers for HPV and with a pair of primers for AdV.
All cases of carcinomas and dysplasia as well as all control cases were negative for both viruses. Four of the five cases of laryngeal papillomas were positive for only HPV, confirming the role of these viral types in the origin of papillomas.
The absence of viral genomes in laryngeal carcinomas as in the other cases studied suggests the existence of other factors that play a more important role than viral infection in the carcinogenesis of these lesions.
探讨人乳头瘤病毒（HPV）和腺病毒（AdV）感染在喉鳞状细胞癌及喉发育异常发生中的作用。
采用计划数据收集的横断面研究。
罗马第一大学G. Ferreri耳鼻喉科及实验医学与病理学系病毒学教研室。
从68例患有喉部良性和恶性病变的患者中获取活检样本。所有组织样本均通过聚合酶链反应，使用两组HPV引物和一对AdV引物进行分析。
所有癌和发育异常病例以及所有对照病例两种病毒检测均为阴性。5例喉乳头状瘤中有4例仅HPV检测呈阳性，证实了这些病毒类型在乳头状瘤起源中的作用。
与其他所研究病例一样，喉癌中不存在病毒基因组，这表明存在其他因素，这些因素在这些病变的致癌过程中比病毒感染发挥着更重要的作用。
