Talan Rommel S, Sanki Aditya K, Sucheck Steven J
Department of Chemistry, The University of Toledo, OH 43606, United States.
Carbohydr Res. 2009 Oct 12;344(15):2048-50. doi: 10.1016/j.carres.2009.07.002. Epub 2009 Jul 12.
N-Glucosyl-2,4-dinitrobenzenesulfonamide was prepared from N-acetyl-d-glucosamine and 2,4-dinitrobenzenesulfonyl chloride. Amidation of several thioacids using the N-glucosylsulfonamide donor proceeded smoothly to give the desired N-glucosylamides in good to high yields. The amidation reactions were carried out at room temperature, under mild conditions, and were completed in a very short time.
N-葡萄糖基-2,4-二硝基苯磺酰胺由N-乙酰基-d-葡萄糖胺和2,4-二硝基苯磺酰氯制备而成。使用N-葡萄糖基磺酰胺供体对几种硫代酸进行酰胺化反应进展顺利，以良好至高收率得到所需的N-葡萄糖基酰胺。酰胺化反应在室温下、温和条件下进行，且在很短时间内完成。
