Ross Judith L, Mazzocco Michele M M, Kushner Harvey, Kowal Karen, Cutler Gordon B, Roeltgen David
Thomas Jefferson University, Department of Pediatrics, Philadelphia, PA 19107, USA.
J Pediatr. 2009 Nov;155(5):714-20. doi: 10.1016/j.jpeds.2009.05.031. Epub 2009 Jul 29.
To study androgen treatment effects on arithmetic performance in girls with Turner syndrome.
Forty-four girls, ages 10 to 14 years at baseline, completed 4 years of treatment with oxandrolone (Ox) or placebo (Pl). All received growth hormone and estrogen replacement therapy. We assessed the number of girls with severe learning disability (LD, standard score <or=5(th) percentile) on measures of academic arithmetic and reading achievement (WRAT-3, arithmetic and reading), given yearly, and the WIAT numerical operations (NOS) and reading subtests, given at year 4.
On the WRAT-3 arithmetic, the frequency of severe arithmetic LD was similar in the Ox and Pl groups at baseline and at years 1 and 2. At years 3 and 4, fewer girls in the Ox than Pl group had a severe arithmetic LD (year 4: 0/22 vs 5/21, P = .02). On the WIAT NOS (year 4), fewer girls in the Ox than Pl groups had a severe arithmetic LD (3/21 vs 8/20, P = .09). WIAT NOS error analysis suggested that the improved performance in the Ox group was associated with better performance on multiplication and division (P < .01). The frequency of severe LD for the WRAT-3 reading was similar for the Ox and Pl groups (all years) and for the WIAT reading subtest (year 4).
Androgen treatment for 4 years in girls with Turner syndrome resulted in a small decrease in frequency of severe arithmetic LD, with no effect on reading LD.
研究雄激素治疗对特纳综合征女孩算术能力的影响。
44名基线年龄为10至14岁的女孩完成了4年的氧雄龙（Ox）或安慰剂（Pl）治疗。所有女孩均接受生长激素和雌激素替代治疗。我们评估了每年在学术算术和阅读成绩测量（WRAT-3，算术和阅读）中严重学习障碍（LD，标准分数≤第5百分位数）女孩的数量，以及在第4年进行的韦氏个别成就测验（WIAT）数字运算（NOS）和阅读子测验。
在WRAT-3算术测试中，Ox组和Pl组在基线以及第1年和第2年时严重算术LD的频率相似。在第3年和第4年，Ox组中严重算术LD的女孩比Pl组少（第4年：0/22 vs 5/21，P = 0.02）。在WIAT NOS（第4年）中，Ox组中严重算术LD的女孩比Pl组少（3/21 vs 8/20，P = 0.09）。WIAT NOS错误分析表明Ox组表现的改善与乘除法表现更好有关（P < 0.01）。Ox组和Pl组在WRAT-3阅读严重LD的频率（所有年份）以及WIAT阅读子测验（第4年）中相似。
特纳综合征女孩接受4年雄激素治疗后，严重算术LD的频率略有下降，对阅读LD无影响。
