The Brain Tumor Center, The University of Chicago, Chicago, IL, USA.
Cancer Lett. 2010 Mar 1;289(1):1-10. doi: 10.1016/j.canlet.2009.04.045. Epub 2009 Jul 29.
Glioblastoma multiforme, the most common primary intracranial malignancy, is associated with very poor outcome despite advances in surgical techniques and chemo- and radiation therapy. Many novel treatment modalities are being investigated with varying amount of success. Evolution of cancer stem cell hypothesis provides a new venue for developmental therapeutics. In this review, we highlight the literature regarding the existence of glioma stem cells and their characteristics. We also discuss the potential for virotherapy, a novel therapeutic approach utilizing conditionally replicative viruses, to directly target this population of self-renewing cancer stem cells.
多形性胶质母细胞瘤是最常见的原发性颅内恶性肿瘤，尽管在手术技术以及化疗和放疗方面取得了进展，但预后仍然很差。许多新的治疗方法正在研究中，取得了不同程度的成功。癌症干细胞假说的发展为开发治疗药物提供了新的途径。在这篇综述中，我们强调了关于神经胶质瘤干细胞的存在及其特征的文献。我们还讨论了病毒疗法的潜力，这是一种利用条件复制病毒的新型治疗方法，以直接针对这种自我更新的癌症干细胞群体。
