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原位肝移植中门静脉动脉化治疗门静脉血栓形成后的长期生存情况。

Long-term survival after portal vein arterialization for portal vein thrombosis in orthotopic liver transplantation.

作者信息

Bonnet S, Sauvanet A, Bruno O, Sommacale D, Francoz C, Dondero F, Durand F, Belghiti J

机构信息

Pôle des maladies de l'appareil digestif, service de chirurgie hépato-biliaire et pancréatique, hôpital Beaujon, AP-HP, université Paris-VII, 100, boulevard du Général-Leclerc, 92110 Clichy, France.

出版信息

Gastroenterol Clin Biol. 2010 Jan;34(1):23-8. doi: 10.1016/j.gcb.2009.05.013. Epub 2009 Jul 29.

Abstract

Portal vein thrombosis is a relatively common finding during liver transplantation. The management of portal vein thrombosis during liver transplantation is technically demanding and ensures adequate portal flow to the liver graft. Eversion thromboendovenectomy and bypass using a patent splanchnic vein and cavoportal hemitransposition are the most often used procedures to treat portal vein thrombosis. There have been anecdotal reports of portal vein arterialization. We report a case of portal vein arterialization during orthotopic liver transplantation for decompensated cirrhosis. When thromboendovenectomy failed to restore sufficient portal flow and completion of arterial anastomosis between the recipient hepatic artery and the donor celiac trunk, a calibrated end-to-side anastomosis between the donor splenic artery and the donor portal vein was performed. With a 6-year follow-up, there are no symptoms related to portal hypertension, liver function is normal. However, an aneurismal dilatation of the portal branches has progressively developed. Calibrated portal vein arterialization is a possible option for portal vein thrombosis in liver transplantation, allowing long-term patient and graft survival.

摘要

门静脉血栓形成是肝移植过程中相对常见的情况。肝移植期间门静脉血栓形成的处理在技术上要求较高,需确保有足够的门静脉血流供应给肝移植物。外翻式血栓内膜切除术以及使用通畅的内脏静脉进行搭桥和腔门静脉半转位是治疗门静脉血栓形成最常用的方法。有关于门静脉动脉化的零星报道。我们报告一例在原位肝移植治疗失代偿期肝硬化过程中发生门静脉动脉化的病例。当血栓内膜切除术未能恢复足够的门静脉血流,且受体肝动脉与供体腹腔干之间完成动脉吻合后,在供体脾动脉与供体门静脉之间进行了校准的端侧吻合。经过6年随访,无门静脉高压相关症状,肝功能正常。然而,门静脉分支出现了动脉瘤样扩张。校准的门静脉动脉化是肝移植中门静脉血栓形成的一种可行选择,可实现患者和移植物的长期存活。

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