唑尼沙胺治疗特发性半面痉挛有效：一例报告

Idiopathic hemifacial spasm responsive to zonisamide: a case report.

作者信息

Siniscalchi Antonio, Gallelli Luca, Palleria Caterina, De Sarro Giovambattista

机构信息

Department of Neuroscience, Neurology Division, Annunziata Hospital, Cosenza, Italy.

出版信息

Clin Neuropharmacol. 2009 Jul-Aug;32(4):230-1. doi: 10.1097/WNF.0b013e31819a68dc.

DOI:10.1097/WNF.0b013e31819a68dc

PMID:19644231

Abstract

AIM

We describe a patient with idiopathic hemifacial spasm (HFS) that was responsive to zonisamide treatment.

METHODS AND RESULTS

A 65-year-old woman presented with a 4-year history of left-sided HFS developing gradually, starting from the upper facial muscles. After several analyses, the diagnosis of idiopathic HFS was made, and the clonazepam treatment (0.5 mg every 8 hours) was started, without a complete remission of symptoms. Therefore, zonisamide (150 mg twice a day for a 6-week period) was added, with a complete resolution. The rechallenge with zonisamide after its dechallenge confirmed its effectiveness. During follow-up, the patient remained symptom-free, with no adverse drug reactions.

CONCLUSIONS

We suggest that zonisamide could represent a useful therapeutic option in the treatment of idiopathic HFS.

摘要

目的

我们描述了一名对唑尼沙胺治疗有反应的特发性面肌痉挛（HFS）患者。

方法与结果

一名65岁女性，有4年左侧HFS病史，起于上部面部肌肉，逐渐发展。经过多项分析，确诊为特发性HFS，开始使用氯硝西泮治疗（每8小时0.5毫克），症状未完全缓解。因此，加用唑尼沙胺（每天两次，每次150毫克，为期6周），症状完全缓解。停用唑尼沙胺后再次使用证实了其有效性。随访期间，患者无症状，无药物不良反应。