阿霉素诱导的心肌病的分子生物学
Molecular biology of doxorubicin-induced cardiomyopathy.
作者信息
Umlauf J, Horký M
机构信息
Masaryk Memorial Cancer Institute and.
出版信息
Exp Clin Cardiol. 2002 Spring;7(1):35-9.
Abstract
The anthracycline doxorubicin is an antineoplastic agent, eliciting chronic cardiac toxicity. It occurs in patients after prolonged administration of doxorubicin, leading to congestive heart failure. The pathogenesis of the doxorubicin-induced car-diomyopathy is not well understood. The present article summarizes the unique effect of doxorubicin on cardiac-specific gene expression. In addition to binding to DNA, doxorubicin directly affects the function of a variety of proteins. Free radical generation, damage to mitochondria and active cell death are also critical in the development of doxorubicin-induced cardiac toxicity. Agents providing effective cardioprotection are also reviewed.
摘要
蒽环类药物阿霉素是一种抗肿瘤药，会引发慢性心脏毒性。它发生在长期使用阿霉素的患者身上，可导致充血性心力衰竭。阿霉素诱导的心肌病的发病机制尚不完全清楚。本文总结了阿霉素对心脏特异性基因表达的独特作用。除了与DNA结合外，阿霉素还直接影响多种蛋白质的功能。自由基生成、线粒体损伤和细胞主动死亡在阿霉素诱导的心脏毒性发展中也起关键作用。本文还综述了提供有效心脏保护作用的药物。
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