使用心肌肌钙蛋白T水平作为多柔比星诱导的心脏毒性的指标。
Use of cardiac troponin T levels as an indicator of doxorubicin-induced cardiotoxicity.
作者信息
Herman E H, Lipshultz S E, Rifai N, Zhang J, Papoian T, Yu Z X, Takeda K, Ferrans V J
机构信息
Division of Applied Pharmacological Research, Food and Drug Administration, Laurel, Maryland 20908, USA.
出版信息
Cancer Res. 1998 Jan 15;58(2):195-7.
The release of cardiac troponin T (cTnT) as a biomarker of doxorubicin-induced chronic cardiac injury was evaluated in the spontaneously hypertensive rat (SHR) model. Elevations in serum levels of cTnT and decreased immunohistochemical staining of heart sections for this protein were noted in SHRs treated with cumulative doses of doxorubicin (7 mg/kg) that induced only minimal histological alterations in myocytes. Concentrations of cTnT were further elevated, coincident with reduced immunohistochemical staining, in SHRs given 10-12 mg/kg doxorubicin. Thus, monitoring serum levels of cTnT can detect doxorubicin-induced myocyte damage in SHR and may prove useful for the noninvasive evaluation of this toxicity in humans.
在自发性高血压大鼠（SHR）模型中评估了心肌肌钙蛋白T（cTnT）作为多柔比星诱导的慢性心脏损伤生物标志物的释放情况。在用累积剂量多柔比星（7 mg/kg）处理的SHR中，观察到血清cTnT水平升高以及心脏切片中该蛋白免疫组化染色减少，而这些多柔比星剂量仅在心肌细胞中引起了最小程度的组织学改变。给予10 - 12 mg/kg多柔比星的SHR中，cTnT浓度进一步升高，同时免疫组化染色减少。因此，监测血清cTnT水平可检测SHR中多柔比星诱导的心肌细胞损伤，并且可能对人类这种毒性的无创评估有用。
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