单绒毛膜双胎中的唐氏综合征
Down syndrome in monochorionic twins.
作者信息
Sin I L, Tan T Y T
机构信息
Raffles Women's Centre, Raffles Hospital, 585 North Bridge Road, #12-00, Singapore.
出版信息
Singapore Med J. 2009 Jul;50(7):e264-7.
Down syndrome in monochorionic twins has rarely been reported. We report such a case diagnosed prenatally. Maternal serum screening was performed at 15 weeks for a twin pregnancy which indicated a risk of greater than 1:50 for Down syndrome. The review of early ultrasonography confirmed monochorionic twins. Amniocentesis at 17 weeks' gestation was performed on one of the twin sacs, which confirmed Down syndrome. A screening scan at 19 weeks' gestation showed isolated absent nasal bones in both twins. Termination of pregnancy was performed subsequently.
单绒毛膜双胎中的唐氏综合征鲜有报道。我们报告了一例产前诊断的此类病例。在孕15周时对双胎妊娠进行了母血清筛查，结果显示唐氏综合征风险大于1:50。早期超声检查复查证实为单绒毛膜双胎。在孕17周时对其中一个羊膜囊进行了羊膜腔穿刺术，确诊为唐氏综合征。孕19周时的筛查超声显示两个胎儿均孤立性鼻骨缺失。随后实施了终止妊娠。
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