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干细胞在再生医学中的可能应用:梦想还是现实?

The possible use of stem cells in regenerative medicine: dream or reality?

机构信息

Department of Traumatology, TU Munich, Klinikum rechts der Isar, Munich, Germany.

出版信息

Langenbecks Arch Surg. 2009 Nov;394(6):985-97. doi: 10.1007/s00423-009-0546-0. Epub 2009 Jul 31.

DOI:10.1007/s00423-009-0546-0
PMID:19644703
Abstract

Stem cells are one of the most fascinating areas in regenerative medicine today. They play a crucial role in the development and regeneration of human life and are defined as cells that continuously reproduce themselves while maintaining the ability to differentiate into various cell types. Stem cells are found at all developmental stages, from embryonic stem cells that differentiate into all cell types found in the human body to adult stem cells that are responsible for tissue regeneration. The general opinion postulates that clinical therapies based on the properties of stem cells may have the potential to change the treatment of degenerative diseases or important traumatic injuries in the "near" future. We here briefly review the literature in particularly for the liver, heart, kidney, cartilage, and bone regeneration.

摘要

干细胞是当今再生医学中最引人关注的领域之一。它们在人类生命的发育和再生中起着至关重要的作用,被定义为能够持续自我复制并具有分化为多种细胞类型能力的细胞。干细胞存在于所有发育阶段,从能够分化为人体所有细胞类型的胚胎干细胞,到负责组织再生的成体干细胞。一般观点假设,基于干细胞特性的临床疗法可能有潜力在“不久的将来”改变退行性疾病或重要创伤性损伤的治疗方法。在这里,我们简要地综述了特别是在肝脏、心脏、肾脏、软骨和骨骼再生方面的文献。

相似文献

1
The possible use of stem cells in regenerative medicine: dream or reality?干细胞在再生医学中的可能应用:梦想还是现实?
Langenbecks Arch Surg. 2009 Nov;394(6):985-97. doi: 10.1007/s00423-009-0546-0. Epub 2009 Jul 31.
2
Advances in regenerative medicine. Advances in Regenerative Medicine, 13 June 2008, BioPark, Hertfordshire, UK.再生医学进展。《再生医学进展》,2008年6月13日,英国赫特福德郡生物园。
Regen Med. 2008 Sep;3(5):769-70. doi: 10.2217/17460751.3.5.769.
3
Potential of human embryonic stem cells in cartilage tissue engineering and regenerative medicine.人胚胎干细胞在软骨组织工程和再生医学中的潜力。
Stem Cell Rev Rep. 2011 Sep;7(3):544-59. doi: 10.1007/s12015-010-9222-6.
4
Kidney regeneration and repair after transplantation.移植后的肾脏再生与修复。
Curr Opin Organ Transplant. 2013 Apr;18(2):191-6. doi: 10.1097/MOT.0b013e32835f0771.
5
The Potential Application of Biomaterials in Cardiac Stem Cell Therapy.生物材料在心脏干细胞治疗中的潜在应用。
Curr Med Chem. 2016;23(6):589-602. doi: 10.2174/092986732306160303151041.
6
Amniotic fluid-derived stem cells in regenerative medicine research.羊膜衍生干细胞在再生医学研究中的应用。
Arch Pharm Res. 2012 Feb;35(2):271-80. doi: 10.1007/s12272-012-0207-7. Epub 2012 Feb 28.
7
Regenerative medicine for the treatment of reproductive system disorders: current and potential options.再生医学治疗生殖系统疾病:当前和潜在的选择。
Adv Drug Deliv Rev. 2015 Mar;82-83:145-52. doi: 10.1016/j.addr.2014.10.019. Epub 2014 Oct 23.
8
Stem Cells for Osteochondral Regeneration.用于骨软骨再生的干细胞。
Adv Exp Med Biol. 2018;1059:219-240. doi: 10.1007/978-3-319-76735-2_10.
9
An overview of the therapeutic potential of regenerative medicine in cutaneous wound healing.再生医学在皮肤伤口愈合中的治疗潜力概述。
Int Wound J. 2017 Jun;14(3):450-459. doi: 10.1111/iwj.12735. Epub 2017 Mar 6.
10
Regenerative medicine in urology.泌尿外科中的再生医学。
Semin Pediatr Surg. 2014 Jun;23(3):106-11. doi: 10.1053/j.sempedsurg.2014.05.002. Epub 2014 May 22.

引用本文的文献

1
Development of a Composite Hydrogel Containing Statistically Optimized PDGF-Loaded Polymeric Nanospheres for Skin Regeneration: In Vitro Evaluation and Stem Cell Differentiation Studies.用于皮肤再生的含统计学优化的负载血小板衍生生长因子的聚合物纳米球复合水凝胶的研制:体外评估与干细胞分化研究
ACS Omega. 2024 Mar 19;9(13):15114-15133. doi: 10.1021/acsomega.3c09391. eCollection 2024 Apr 2.
2
Osteogenic effects of rapamycin on bone marrow mesenchymal stem cells via inducing autophagy.雷帕霉素通过诱导自噬对骨髓间充质干细胞的成骨作用。
J Orthop Surg Res. 2023 Feb 22;18(1):129. doi: 10.1186/s13018-023-03616-9.
3
Therapeutic mesenchymal stromal stem cells: Isolation, characterization and role in equine regenerative medicine and metabolic disorders.

本文引用的文献

1
The BALANCE Study: clinical benefit and long-term outcome after intracoronary autologous bone marrow cell transplantation in patients with acute myocardial infarction.BALANCE研究:急性心肌梗死患者冠状动脉内自体骨髓细胞移植后的临床益处及长期预后
J Am Coll Cardiol. 2009 Jun 16;53(24):2262-9. doi: 10.1016/j.jacc.2009.02.051.
2
Differentiation of monkey embryonic stem cells into hepatocytes and mRNA expression of cytochrome p450 enzymes responsible for drug metabolism: comparison of embryoid body formation conditions and matrices.猴胚胎干细胞向肝细胞的分化及负责药物代谢的细胞色素P450酶的mRNA表达:胚状体形成条件和基质的比较
Biol Pharm Bull. 2009 Apr;32(4):619-26. doi: 10.1248/bpb.32.619.
3
治疗性间充质基质干细胞:在马再生医学和代谢紊乱中的分离、鉴定和作用。
Stem Cell Rev Rep. 2020 Apr;16(2):301-322. doi: 10.1007/s12015-019-09932-0.
4
Animal mesenchymal stem cell research in cartilage regenerative medicine - a review.动物间充质干细胞在软骨再生医学中的研究——综述
Vet Q. 2019 Dec;39(1):95-120. doi: 10.1080/01652176.2019.1643051.
5
Evaluation of different commercial hyaluronic acids as a vehicle for injection of human adipose-derived mesenchymal stem cells.评估不同商业透明质酸作为注射人脂肪间充质干细胞载体的效果。
Rev Bras Ortop. 2018 Aug 2;53(5):557-563. doi: 10.1016/j.rboe.2018.07.009. eCollection 2018 Sep-Oct.
6
Rapid Rapamycin-Only Induced Osteogenic Differentiation of Blood-Derived Stem Cells and Their Adhesion to Natural and Artificial Scaffolds.仅雷帕霉素快速诱导血液来源干细胞的成骨分化及其与天然和人工支架的黏附
Stem Cells Int. 2017;2017:2976541. doi: 10.1155/2017/2976541. Epub 2017 Jul 26.
7
Stem cell procedures in arthroscopic surgery.关节镜手术中的干细胞治疗方法。
Eur J Med Res. 2016 Jul 13;21(1):29. doi: 10.1186/s40001-016-0224-y.
8
Recent biological trends in management of fracture non-union.骨折不愈合治疗的近期生物学趋势
World J Orthop. 2015 Sep 18;6(8):623-8. doi: 10.5312/wjo.v6.i8.623.
9
Fueling Hope: Stem Cells in Social Media.为希望加油:社交媒体中的干细胞。
Stem Cell Rev Rep. 2015 Aug;11(4):540-6. doi: 10.1007/s12015-015-9591-y.
10
Calcium alginate gels as stem cell matrix-making paracrine stem cell activity available for enhanced healing after surgery.海藻酸钙凝胶作为干细胞基质可产生旁分泌干细胞活性,有助于术后加速愈合。
PLoS One. 2015 Mar 20;10(3):e0118937. doi: 10.1371/journal.pone.0118937. eCollection 2015.
One liver for four children: first clinical series of liver cell transplantation for severe neonatal urea cycle defects.
一个肝脏供四个孩子:严重新生儿尿素循环障碍肝细胞移植的首个临床系列研究
Transplantation. 2009 Mar 15;87(5):636-41. doi: 10.1097/TP.0b013e318199936a.
4
Human embryonic stem cell technologies and drug discovery.人类胚胎干细胞技术与药物研发
J Cell Physiol. 2009 Jun;219(3):513-9. doi: 10.1002/jcp.21732.
5
Reprogramming of murine and human somatic cells using a single polycistronic vector.使用单一多顺反子载体对小鼠和人类体细胞进行重编程。
Proc Natl Acad Sci U S A. 2009 Jan 6;106(1):157-62. doi: 10.1073/pnas.0811426106. Epub 2008 Dec 24.
6
Transplantation of monocyte-derived hepatocyte-like cells (NeoHeps) improves survival in a model of acute liver failure.单核细胞衍生的肝样细胞(NeoHeps)移植可提高急性肝衰竭模型的生存率。
Ann Surg. 2009 Jan;249(1):149-54. doi: 10.1097/SLA.0b013e31818a1543.
7
Generation of rat and human induced pluripotent stem cells by combining genetic reprogramming and chemical inhibitors.通过基因重编程与化学抑制剂相结合生成大鼠和人类诱导多能干细胞。
Cell Stem Cell. 2009 Jan 9;4(1):16-9. doi: 10.1016/j.stem.2008.11.014. Epub 2008 Dec 18.
8
Blood group ABO antigen expression in human embryonic stem cells and in differentiated hepatocyte- and cardiomyocyte-like cells.人类胚胎干细胞以及分化的肝细胞样细胞和心肌细胞样细胞中的ABO血型抗原表达。
Transplantation. 2008 Nov 27;86(10):1407-13. doi: 10.1097/TP.0b013e31818a6805.
9
Hepatocyte differentiation of mesenchymal stem cells from human adipose tissue in vitro promotes hepatic integration in vivo.人脂肪组织间充质干细胞在体外向肝细胞分化可促进其在体内的肝整合。
Gut. 2009 Apr;58(4):570-81. doi: 10.1136/gut.2008.154880. Epub 2008 Nov 20.
10
Improving safety of gene therapy.提高基因治疗的安全性。
Curr Drug Saf. 2008 Jan;3(1):46-53. doi: 10.2174/157488608783333925.