正常干细胞与癌症干细胞的特征描述：两种干细胞的一种实验范式
Characterisation of normal and cancer stem cells: one experimental paradigm for two kinds of stem cells.
作者信息
Mayol Jean-François, Loeuillet Corinne, Hérodin Francis, Wion Didier
机构信息
Centre de Recherches du Service de Santé des Armées, P.O. Box 87, 38702 La Tronche, France.
出版信息
Bioessays. 2009 Sep;31(9):993-1001. doi: 10.1002/bies.200900041.
The characterisation of normal stem cells and cancer stem cells uses the same paradigm. These cells are isolated by a fluorescence-activated cell sorting step and their stemness is assayed following implantation into animals. However, differences exist between these two kinds of stem cells. Therefore, the translation of the experimental procedures used for normal stem cell isolation into the research field of cancer stem cells is a potential source of artefacts. In addition, normal stem cell therapy has the objective of regenerating a tissue, while cancer stem cell-centred therapy seeks the destruction of the cancer tissue. Taking these differences into account is critical for anticipating problems that might arise in cancer stem cell-centred therapy and for upgrading the cancer stem cell paradigm accordingly.
正常干细胞和癌症干细胞的特征描述采用相同的模式。这些细胞通过荧光激活细胞分选步骤进行分离，并且在植入动物体内后检测其干性。然而，这两种干细胞之间存在差异。因此，将用于正常干细胞分离的实验程序应用于癌症干细胞研究领域可能会产生假象。此外，正常干细胞治疗的目的是使组织再生，而以癌症干细胞为中心的治疗则旨在破坏癌症组织。考虑到这些差异对于预测以癌症干细胞为中心的治疗中可能出现的问题以及相应地改进癌症干细胞模式至关重要。
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