1级乳腺癌治疗后进行随访可能并无益处。
Follow-up may not be beneficial after treatment of grade 1 breast cancer.
作者信息
Kontos M, Allen D, Trafalis D T, Jones G, Garmo H, Holmberg L, Hamed H
机构信息
Breast Unit, Guy's Hospital, London, UK.
出版信息
Br J Surg. 2009 Sep;96(9):999-1004. doi: 10.1002/bjs.6669.
BACKGROUND
Identification of women treated for breast cancer who have a low risk of locoregional recurrence or contralateral breast cancer, and who can be discharged safely from follow-up, would lower costs without compromising prognosis. This study investigated the risk of locoregional recurrence and contralateral breast cancer in women treated for grade 1 breast cancer.
METHODS
Some 1143 women who had surgery for breast cancer were followed, and the rate of locoregional recurrence or contralateral breast cancer was determined. The risk was compared to the tumour grade.
RESULTS
At a mean follow-up of 9.1 years, 10-year estimates of the cumulative risk of locoregional recurrence or contralateral breast cancer for grade 1, 2 and 3 breast cancer were 0.03 (95 per cent confidence interval (c.i.) 0.01 to 0.08), 0.12 (0.09 to 0.15) and 0.16 (0.13 to 0.20) respectively. Grade 1 tumours had a risk of locoregional recurrence or contralateral breast cancer of 285 (95 per cent c.i. 93 to 670) per 100,000 person-years.
CONCLUSION
Women treated for grade 1 breast cancer could be discharged from follow-up after completion of the primary treatment, without compromising their quality of care.
背景
识别那些局部区域复发或对侧乳腺癌风险较低、且可安全终止随访的乳腺癌治疗女性患者，既能降低成本，又不影响预后。本研究调查了1级乳腺癌治疗女性患者的局部区域复发和对侧乳腺癌风险。
方法
对约1143例接受乳腺癌手术的女性进行随访，确定局部区域复发或对侧乳腺癌的发生率，并与肿瘤分级进行风险比较。
结果
平均随访9.1年时，1级、2级和3级乳腺癌的局部区域复发或对侧乳腺癌10年累积风险估计值分别为0.03（95%置信区间（c.i.）0.01至0.08）、0.12（0.09至0.15）和0.16（0.13至0.20）。1级肿瘤的局部区域复发或对侧乳腺癌风险为每100,000人年285例（95% c.i. 93至670）。
结论
1级乳腺癌治疗女性患者在完成初始治疗后可终止随访，而不影响其护理质量。
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