Scavo D, Barletta C, Vagiri D, Burla F, Fontana M, Lazzari R
I Cattedra di Patologia Speciale Medica e Metodologia Clinica, Università degli Studi di Roma La Sapienza, Italia.
Physiol Behav. 1990 Nov;48(5):681-3. doi: 10.1016/0031-9384(90)90211-l.
In seventy-two patients affected by hyperphagic obesity and forty age-matched, normal weight volunteers we performed a psychological assessment, through various mental tests, and evaluated the beta-endorphin (B-Ep), ACTH and cortisol circulating levels, in basal condition and following an overnight short dexamethasone suppression test (DST). The hormones were measured by radioimmunoassay either directly in the serum (cortisol) and the plasma (ACTH), or after affinity gel column chromatography (B-Ep). In obese subjects B-Ep levels in basal conditions were four times greater than in normal weight controls and showed significantly less reduction after DST. ACTH and cortisol levels, in contrast, were in the normal range and were suppressed following dexamethasone as was also true in the control group. Psychological evaluation on M.M.P.I. (Minnesota Multiphasic Personality Inventory) revealed a trend toward hypochondria, depression, hysterias, psychoasthenia and schizophrenia. However, no significant correlation has been found between M.M.P.I. clinical scale scores and circulating levels of B-Ep and cortisol either in basal conditions or after DST. In conclusion, these data do not support the hypothesis that abnormalities of the hypothalamus-pituitary-adrenal axis in hyperphagic obesity are related to affective disorders.
在72例食欲亢进性肥胖患者和40名年龄匹配的正常体重志愿者中，我们通过各种心理测试进行了心理评估，并评估了基础状态下以及过夜小剂量地塞米松抑制试验（DST）后β-内啡肽（B-Ep）、促肾上腺皮质激素（ACTH）和皮质醇的循环水平。激素通过放射免疫分析法直接在血清（皮质醇）和血浆（ACTH）中测量，或在亲和凝胶柱色谱法后（B-Ep）测量。在肥胖受试者中，基础状态下的B-Ep水平是正常体重对照组的四倍，并且在DST后降低明显较少。相比之下，ACTH和皮质醇水平在正常范围内，并且地塞米松后被抑制，对照组也是如此。明尼苏达多相人格调查表（M.M.P.I.）的心理评估显示有疑病症、抑郁症、癔症、精神衰弱和精神分裂症的趋势。然而，在基础状态下或DST后，未发现M.M.P.I.临床量表评分与B-Ep和皮质醇的循环水平之间存在显著相关性。总之，这些数据不支持食欲亢进性肥胖中下丘脑-垂体-肾上腺轴异常与情感障碍相关的假设。
