Alebiowu Gbenga, Adeyemi Ayoade O
Department of Pharmaceutics, Faculty of Pharmacy, Obafemi Awolowo University, Ile-Ife, Nigeria.
Acta Pol Pharm. 2009 May-Jun;66(3):311-20.
In this study, tapioca starches obtained after different steeping periods, i.e. TS 24, TS 48 and TS 72, were used as disintegrants with corn starch BP as the standard disintegrant in a paracetamol tablet formulation. Two dimensionless disintegration quantities, T(N) and T(C) were used in the determination of the influence that steeping period of starch disintegrant would have on the crushing strength friability-disintegration time ratio (CSFR/DT). These quantities were used to assess the influence of steeping period, relative density and disintegrant concentration on CSFR/DT as well as to compare disintegrant efficiency. The results suggest that the CSFR/DT is more dependent on the disintegrant concentration than on steeping period and relative density. The study further showed that TS 72 is a more reliable disintegrant because its activity would not be influenced by changes in relative density of tablets. This work concludes that the T(N) would be more useful for quantitative assessment while T(C) is more relevant for qualitative assessment.
在本研究中，将经过不同浸泡时间（即TS 24、TS 48和TS 72）获得的木薯淀粉用作扑热息痛片剂配方中的崩解剂，以玉米淀粉BP作为标准崩解剂。在测定淀粉崩解剂的浸泡时间对抗压强度与脆碎度-崩解时间比（CSFR/DT）的影响时，使用了两个无量纲崩解量T(N)和T(C)。这些量用于评估浸泡时间、相对密度和崩解剂浓度对CSFR/DT的影响，以及比较崩解剂效率。结果表明，CSFR/DT对崩解剂浓度的依赖性比对浸泡时间和相对密度的依赖性更大。该研究进一步表明，TS 72是一种更可靠的崩解剂，因为其活性不会受到片剂相对密度变化的影响。这项工作得出结论，T(N)对于定量评估更有用，而T(C)对于定性评估更相关。
