Exp Dermatol. 2010 Jan;19(1):62-4. doi: 10.1111/j.1600-0625.2009.00940.x. Epub 2009 Jul 23.
Vitiligo is a common, non-contagious disorder. The basic pathogenesis of vitiligo generally, or for any of the putative subsets of vitiligo, remains unknown. The liver X receptors (LXRs), LXR-alpha and LXR-beta are members of the nuclear hormone receptor superfamily of ligand-activated transcription factors. Important genes involved in regulation of melanocytes are target genes of LXRs; it can be speculated that LXRs might be playing an important role in pathogenesis of pigmentary disorders. We have demonstrated in this study that there is expression of LXR-alpha/beta by human melanocytes at both transcriptional and translational levels. Our present data also revealed that the expression of LXR-alpha at both mRNA and protein level was significantly higher in perilesional skin as compared to the normal skin of vitiligo patient.
白癜风是一种常见的非传染性疾病。白癜风的基本发病机制一般或任何假定的白癜风亚群仍然未知。肝 X 受体 (LXRs)，LXR-α和 LXR-β是配体激活转录因子的核激素受体超家族的成员。参与黑素细胞调节的重要基因是 LXRs 的靶基因；可以推测，LXRs 可能在色素障碍的发病机制中发挥重要作用。我们在这项研究中证明了人类黑素细胞在转录和翻译水平上均有 LXR-α/β的表达。我们目前的数据还显示，与白癜风患者正常皮肤相比，白癜风皮损皮肤中 LXR-α 的 mRNA 和蛋白水平表达显著升高。
