Gleich S, Hartmann K
Clinic of Small Animal Internal Medicine, Ludwig Maximilian University Munich, Munich, Germany.
J Vet Intern Med. 2009 May-Jun;23(3):552-8. doi: 10.1111/j.1939-1676.2009.0303.x.
Hematological and biochemical values in cats naturally infected by feline immunodeficiency virus (FIV) or feline leukemia virus (FeLV) are not completely documented.
Report differences in laboratory values between FIV- or FeLV-infected and noninfected and between FIV- and FeLV-infected cats.
Three thousand seven hundred and eighty client-owned cats tested for FIV and FeLV.
Retrospective study. Evaluation of clinicopathologic changes in cats with defined FIV and FeLV status and for which laboratory data were available.
FIV-infected cats were more likely to be neutropenic (odds ratio [OR]=3.6, 95% confidence interval [95% CI] 2.1-6.2, P < .0001) and had lower serum activities of aspartate aminotransferase and glutamate dehydrogenase than control cats; serum total protein (8.1 +/- 1.1 versus 7.6 +/- 1.3 g/dL, P < .001) and gamma-globulin concentrations (2.2 +/- 1.1 versus 1.7 +/- 1.3 g/dL, P < .001) were higher than in uninfected cats. Compared with controls, FeLV-infected cats had a higher risk of anemia (OR = 3.8, 95% CI 2.4-6.0, P < .0001), thrombocytopenia (OR = 5.0, 95% CI 3.0-8.4, P < .0001), neutropenia (OR = 3.6, 95% CI 2.1-6.1, P < .0001), lymphocytosis (OR = 2.8, 95% CI 1.6-4.8, P= .0002), and lower erythrocyte counts (6.13 +/- 2.95 x 10(3) versus 8.72 +/- 2.18 x 10(3)/microL, P < .001), thrombocyte counts (253.591 +/- 171.841 x 10(3) versus 333.506 +/- 156.033 x 10(3)/microL, P < .001), hematocrit (28.72 +/- 12.86 versus 37.67 +/- 8.90%, P < .001), hemoglobin and creatinine concentration.
Hematologic abnormalities are common in FeLV-infected but not in FIV-infected cats. Clinicopathologic abnormalities are less frequent in FIV-infected cats and might reflect an unspecific immunologic response.
猫自然感染猫免疫缺陷病毒（FIV）或猫白血病病毒（FeLV）后的血液学和生化指标尚未完全记录。
报告FIV或FeLV感染猫与未感染猫之间以及FIV感染猫与FeLV感染猫之间实验室指标的差异。
3780只接受FIV和FeLV检测的客户拥有的猫。
回顾性研究。评估明确FIV和FeLV感染状态且有实验室数据的猫的临床病理变化。
FIV感染猫更易出现中性粒细胞减少（优势比[OR]=3.6，95%置信区间[95%CI]2.1 - 6.2，P <.0001），且天冬氨酸转氨酶和谷氨酸脱氢酶的血清活性低于对照猫；血清总蛋白（8.1±1.1对7.6±1.3 g/dL，P <.001）和γ-球蛋白浓度（2.2±1.1对1.7±1.3 g/dL，P <.001）高于未感染猫。与对照组相比，FeLV感染猫患贫血（OR = 3.8，95%CI 2.4 - 6.0，P <.0001）、血小板减少（OR = 5.0，95%CI 3.0 - 8.4，P <.0001）、中性粒细胞减少（OR = 3.6，95%CI 2.1 - 6.1，P <.0001）、淋巴细胞增多（OR = 2.8，95%CI 1.6 - 4.8，P =.0002）的风险更高，且红细胞计数（6.13±2.95×10³对8.72±2.18×10³/μL，P <.001）、血小板计数（253.591±171.841×10³对333.506±156.033×10³/μL，P <.001）、血细胞比容（28.72±12.86对37.67±8.90%，P <.001）、血红蛋白和肌酐浓度更低。
血液学异常在FeLV感染猫中常见，但在FIV感染猫中不常见。FIV感染猫的临床病理异常较少见，可能反映了一种非特异性免疫反应。
