Exp Dermatol. 2010 Jan;19(1):65-7. doi: 10.1111/j.1600-0625.2009.00938.x. Epub 2009 Jul 23.
Erythropoietin (EPO) is now appreciated for not only drive erythopoiesis, but also to exert additional functions. Since we had previously shown that human hair follicles (HFs) are both an extra-renal source and an extra-medullary target of EPO, we have now studied whether one such function is the regulation of HF pigmentation. Human anagen VI HFs were treated with EPO (100 IU/ml) in serum-free organ culture. Unexpectedly, we noticed greatly divergent pigmentary effects of EPO, since both up- and down-regulation of HF melanin content and tyrosinase activity in situ was seen in HF derived from different individuals. These divergent effects could not be attributed to differences in skin regions, the total HF melanocyte number or specific traits of individual HF donors. Our pilot study provides first evidence suggesting that EPO may modulate normal human melanocyte functions under physiologically relevant conditions in situ.
促红细胞生成素 (EPO) 不仅可以促进红细胞生成，还具有其他额外的功能。因为我们之前已经表明，人类毛囊 (HFs) 既是 EPO 的肾脏外来源，也是骨髓外靶标，所以我们现在研究了它的一个功能是否是调节 HF 的色素沉着。我们用人血清无器官培养物处理处于生长期 VI 期的人毛囊。出人意料的是，我们注意到 EPO 产生了非常不同的色素沉着效果，因为我们在不同个体来源的毛囊中均观察到了原位 HF 黑色素含量和酪氨酸酶活性的上调和下调。这些不同的效果不能归因于皮肤区域、HF 黑素细胞总数或个体 HF 供体的特定特征的差异。我们的初步研究提供了第一个证据，表明 EPO 可以在生理相关条件下调节正常人黑素细胞的功能。
