Brandt Thomas, Glasauer Stefan, Strupp Michael, Dieterich Marianne
Institute of Clinical Neurosciences, Ludwig-Maximilians University, Munich, Germany.
Ann N Y Acad Sci. 2009 May;1164:216-21. doi: 10.1111/j.1749-6632.2009.03860.x.
Schematic drawings are presented of the major anatomical structures involved, along with their functional excitatory and inhibitory connections as the basis of a hypothetical model of visuospatial neglect. It is assumed that multisensory integration centers for attention and orientation (MSO) are represented in the temporo-parietal cortex of both hemispheres, with the dominant MSO being in the right hemisphere (nondominant hemisphere in right-handedness). A lesion of the dominant MSO will cause a left-sided neglect due to a lack of ipsilateral activation of the visual cortex, which is further enhanced by increased inhibition from the contralateral visual cortex. The nondominant MSO in the left hemisphere might be involved in the manifestation of the less frequent and more transient right-sided neglect and in the plastic mechanisms of gradual recovery from a left-sided neglect or extinction.
文中呈现了所涉及的主要解剖结构的示意图，以及它们的功能性兴奋和抑制连接，作为视觉空间忽视假说模型的基础。假设注意力和定向的多感觉整合中心（MSO）存在于双侧半球的颞顶叶皮层，其中占主导地位的MSO位于右半球（右利手者的非优势半球）。占主导地位的MSO损伤会导致左侧忽视，这是由于视觉皮层同侧激活不足，对侧视觉皮层抑制增加进一步加剧了这种情况。左半球的非主导MSO可能参与较罕见且更短暂的右侧忽视的表现，以及从左侧忽视或消退中逐渐恢复的可塑性机制。
