Watson D K, Ascione R, Papas T S
Laboratory of Molecular Oncology, National Cancer Institute, Frederick, Maryland.
Crit Rev Oncog. 1990;1(4):409-36.
Organisms from human to Drosophila have been found to contain cellular sequences and transcripts that are homologous to the ets region of the avian retrovirus, E26. Ets-related sequences are present on at least two distinct functional loci in chickens and mammals, and have been designated ets-1 and ets-2. The E26 virus transduced sequences from the chicken ets-1 locus, which encompasses over 60 kb of DNA. The ets genes characterized so far from sea urchin and Drosophila are most closely related to the 3' end of the known ets genes. The predicted viral and avian ets proteins are very similar, except at the termini. The similarity between the predicted ets proteins so far described is discussed. The ets proteins have been identified and localized by immunoprecipitation and immunofluorescence. While the ets-1 proteins are found in the nuclear and cytoplasmic fractions, the viral gag-myb-ets protein (p135) and the ets-2 proteins are nuclear. The ets-1 and ets-2 genes are differentially regulated in different cell types, probably reflecting unique controlling elements. Because chromosomal translocations have been associated with different human leukemias, studies addressing the possible association with the ETS1 (11q23) or ETS2 (21q22.3) loci are reviewed.
从人类到果蝇的生物体中都已发现含有与禽逆转录病毒E26的ets区域同源的细胞序列和转录本。与ets相关的序列存在于鸡和哺乳动物的至少两个不同的功能基因座上，并已被命名为ets-1和ets-2。E26病毒转导了来自鸡ets-1基因座的序列，该基因座包含超过60 kb的DNA。到目前为止，从海胆和果蝇中鉴定出的ets基因与已知ets基因的3'端关系最为密切。预测的病毒和禽类ets蛋白非常相似，只是在末端有所不同。讨论了目前所描述的预测ets蛋白之间的相似性。ets蛋白已通过免疫沉淀和免疫荧光进行了鉴定和定位。虽然ets-1蛋白存在于细胞核和细胞质部分，但病毒gag-myb-ets蛋白（p135）和ets-2蛋白存在于细胞核中。ets-1和ets-2基因在不同细胞类型中受到不同的调控，这可能反映了独特的控制元件。由于染色体易位与不同类型的人类白血病有关，因此对涉及与ETS1（11q23）或ETS2（21q22.3）基因座可能关联的研究进行了综述。
