Dirikolu L, Woods W E, Boyles J, Lehner A F, Harkins J D, Fisher M, Schaeffer D J, Tobin T
Department of Veterinary Bioscience, College of Veterinary Medicine, University of Illinois, Urbana, IL 61802, USA.
J Vet Pharmacol Ther. 2009 Jun;32(3):271-9. doi: 10.1111/j.1365-2885.2008.01038.x.
Injuries sustained by horses during racing have been considered as an unavoidable part of horse racing. Many factors may be associated with the musculoskeletal injuries of Thoroughbred race horses. This study surveyed the amounts of nonsteroidal anti-inflammatory agents (NSAIDs) in injured horse's biological system (plasma) at Kentucky racetracks from January 1, 1995 through December 31, 1996. During that period, there were 84 catastrophic cases (euthanized horses) and 126 noncatastrophic cases. Plasma concentrations of NSAIDs were determined by High Performance Liquid Chromatography in injured and control horses. The possible role of anti-inflammatory agents in musculoskeletal injuries of Thoroughbred race horses was investigated by comparing the apparent concentrations of NSAIDs in injured horses to concentrations in control horses. The plasma concentrations of phenylbutazone and flunixin were higher in injured horses than in control horses. Most injured and control horses did not have a detectable level of naproxen in their plasma samples. Further studies must be carried out to determine whether horses with higher plasma concentrations of NSAIDs have an altered risk of musculoskeletal injuries compared with other horses.
马匹在比赛中受到的伤害一直被视为赛马运动不可避免的一部分。许多因素可能与纯种赛马的肌肉骨骼损伤有关。本研究调查了1995年1月1日至1996年12月31日期间肯塔基赛马场受伤马匹生物系统（血浆）中非甾体抗炎药（NSAIDs）的含量。在此期间，有84例灾难性病例（实施安乐死的马匹）和126例非灾难性病例。通过高效液相色谱法测定受伤马匹和对照马匹血浆中NSAIDs的浓度。通过比较受伤马匹与对照马匹中NSAIDs的表观浓度，研究了抗炎药在纯种赛马肌肉骨骼损伤中的可能作用。受伤马匹血浆中苯基布他松和氟尼辛的浓度高于对照马匹。大多数受伤马匹和对照马匹的血浆样本中未检测到萘普生水平。必须进行进一步研究，以确定与其他马匹相比，血浆中NSAIDs浓度较高的马匹肌肉骨骼损伤风险是否有所改变。
