重新审视23-碘螺旋甾烷。新事实与全面表征。
Revisiting 23-iodospirostanes. New facts and full characterization.
作者信息
Ruíz-Pérez Karen M, Romero-Avila Margarita, Flores-Pérez Blas, Flores-Alamo Marcos, Moreno-Esparza Rafael, Iglesias-Arteaga Martín A
机构信息
Facultad de Química, Universidad Nacional Autónoma de México, Ciudad Universitaria, 04510 México, D.F., Mexico.
出版信息
Steroids. 2009 Nov;74(12):996-1002. doi: 10.1016/j.steroids.2009.07.008. Epub 2009 Jul 29.
In addition to a previous report, the reaction of tigogenin acetate with ICl in refluxing CHCl(3) produced the hitherto unknown 23R-iodotigogenin acetate, bearing an axial iodine atom at C-23 and its already reported 23S-epimer. The same treatment of sarsasapogenin acetate led to a single diasteromer characterized as 23S-iodosarsasapogenin acetate. A full characterization of the obtained compound including (1)H, (13)C NMR, MS and X-ray diffraction is provided.
除了之前的一份报告外，醋酸替告皂苷元与氯化碘在回流的三氯甲烷中反应，生成了迄今未知的23R-碘代醋酸替告皂苷元，其C-23位带有一个轴向碘原子，以及其已报道的23S-差向异构体。对醋酸菝葜皂苷元进行相同处理，得到了单一的非对映异构体，其被表征为23S-碘代醋酸菝葜皂苷元。文中提供了所获化合物的全面表征，包括氢谱、碳谱核磁共振、质谱和X射线衍射分析结果。
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