Department of Environmental and Preventive Medicine, Hyogo College of Medicine, Mukogawa-cho 1-1, Nishinomiya, Hyogo 663-8501, Japan.
Prev Med. 2009 Nov;49(5):374-9. doi: 10.1016/j.ypmed.2009.07.015. Epub 2009 Jul 29.
To determine whether body weight influences the associations of habitual alcohol drinking with blood pressure and serum lipids in women.
The subjects were 16,805 healthy women at ages of 35-54 years, and data were collected at work places of the subjects in Yamagata Prefecture in Japan from April 1999 to March 2000. The subjects were divided into three tertile groups of body weight and were further divided into three subgroups by average ethanol intake [non-, light (<15 g per day), and heavy (> or =15 g per day) drinkers].
In the first and second tertile groups of body weight, mean systolic and diastolic blood pressure and prevalence of high systolic or diastolic blood pressure were significantly higher in heavy drinkers than in non-drinkers, while these differences were not observed in the third tertile group of body weight. On the other hand, in all tertile groups of body weight, mean serum HDL and LDL cholesterol levels were higher and lower, respectively, in light and heavy drinkers than in non-drinkers, and prevalence of low HDL cholesterol or high LDL cholesterol was significantly lower in heavy drinkers than in non-drinkers.
The results suggest that body weight influences the association of alcohol drinking with blood pressure but not the associations of alcohol drinking with serum HDL and LDL cholesterol.
确定体重是否会影响习惯性饮酒与女性血压和血清脂质之间的关联。
研究对象为日本山形县工作场所年龄在 35-54 岁的 16805 名健康女性，数据收集于 1999 年 4 月至 2000 年 3 月。根据体重将研究对象分为三组，并根据平均乙醇摄入量[非饮酒者（<15 克/天）、轻度饮酒者（15 克/天）和重度饮酒者（>=15 克/天）]进一步分为三个亚组。
在体重的第一和第二三分位组中，重度饮酒者的收缩压和舒张压均值以及高血压患病率均显著高于非饮酒者，而在体重的第三三分位组中则未观察到这些差异。另一方面，在所有体重三分位组中，与非饮酒者相比，轻、重度饮酒者的血清高密度脂蛋白（HDL）和低密度脂蛋白（LDL）胆固醇水平分别升高和降低，且重度饮酒者的低 HDL 胆固醇或高 LDL 胆固醇患病率显著低于非饮酒者。
这些结果表明，体重会影响饮酒与血压之间的关联，但不会影响饮酒与血清 HDL 和 LDL 胆固醇之间的关联。
