新型受体拮抗剂ONO - 1078对豚鼠内源性白三烯介导的肺过敏反应的抑制作用

Inhibition of endogenous leukotriene-mediated lung anaphylaxis in guinea pigs by a novel receptor antagonist ONO-1078.

作者信息

Ishii A, Nakagawa T, Nambu F, Motoishi M, Miyamoto T

机构信息

Department of Medicine and Physical Therapy, University of Tokyo, Japan.

出版信息

Int Arch Allergy Appl Immunol. 1990;92(4):404-7. doi: 10.1159/000235172.

DOI:10.1159/000235172

PMID:1964674

Abstract

The inhibitory effect of ONO-1078, a novel leukotriene (LT) receptor antagonist, was investigated on guinea pig lung anaphylaxis in vitro and in vivo. It was demonstrated that this compound could inhibit the late phase of contractile responses in Schultz-Dale reactions and endogenous LT-mediated bronchoconstrictions in passively sensitized guinea pigs, in a dose-dependent fashion, implying its clinical usefulness in the treatment of human bronchial asthma.

摘要

新型白三烯（LT）受体拮抗剂ONO-1078对豚鼠肺过敏反应的体外和体内抑制作用进行了研究。结果表明，该化合物能以剂量依赖的方式抑制舒尔茨-戴尔反应中收缩反应的晚期阶段以及被动致敏豚鼠体内内源性LT介导的支气管收缩，这意味着它在治疗人类支气管哮喘方面具有临床应用价值。