乳腺单纯型导管内乳头状瘤中的癌。
Carcinoma within solitary ductal papilloma of the breast.
机构信息
Departments of Surgery A&B, Rabin Medical Center, Beilinson Campus, Petach Tikva and Sackler School of Medicine, Tel Aviv University, Tel Aviv 49100, Israel.
出版信息
Eur J Surg Oncol. 2010 Apr;36(4):384-6. doi: 10.1016/j.ejso.2009.07.001. Epub 2009 Jul 31.
BACKGROUND
Solitary ductal papilloma of the breast, traditionally considered a benign disorder, was recently found to have malignant potential, especially when associated with atypical ductal hyperplasia.
METHODS
All patients diagnosed with solitary ductal papilloma at a tertiary medical center from 1994 to 2004 were identified by a database search. Background, clinical and pathological data were collected for those with a carcinoma within the papilloma, and their pathological specimens were revised.
RESULTS
Of the 3849 breast biopsies performed in our medical center during the study period, 77 (2%) yielded a solitary ductal papilloma. In 12 cases (15.6% of all solitary ductal papillomas; 0.3% of all breast biopsies), a carcinoma was found within the papilloma. Ten were diagnosed as carcinoma in situ and 2 as microinvasive carcinoma.
CONCLUSION
In the present series, the incidence of carcinoma within solitary ductal papilloma was 15.6%, indicating that solitary ductal papillomas have malignant potential.
SUMMARY
Carcinoma within solitary ductal papilloma of the breast was found in 15.6% of all papillomas. This seems to indicate a malignant potential of papillomas and the need for surgical excision.
背景
乳腺单纯性导管内乳头状瘤，传统上被认为是一种良性疾病，但最近发现其具有恶性潜能，尤其是当与非典型导管增生并存时。
方法
通过数据库搜索，确定了 1994 年至 2004 年在一家三级医疗中心诊断为单纯性导管内乳头状瘤的所有患者。收集了乳头状瘤内有癌的患者的背景、临床和病理资料，并对其病理标本进行了修订。
结果
在研究期间，我们医疗中心进行的 3849 例乳腺活检中，有 77 例（2%）为单纯性导管内乳头状瘤。在 12 例（所有单纯性导管内乳头状瘤的 15.6%；所有乳腺活检的 0.3%）中，在乳头状瘤内发现了癌。其中 10 例诊断为原位癌，2 例为微浸润癌。
结论
在本系列中，单纯性导管内乳头状瘤内癌的发生率为 15.6%，表明单纯性导管内乳头状瘤具有恶性潜能。
总结
乳腺单纯性导管内乳头状瘤中发现癌的比例为 15.6%，这似乎表明了乳头状瘤的恶性潜能，需要进行手术切除。
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