Pardoll Drew
Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
Cancer Cell. 2009 Aug 4;16(2):81-2. doi: 10.1016/j.ccr.2009.07.007.
While the role of endogenous T cells in antitumor immunity is being debated, little is known about whether and how T cells promote tumorigenesis. In this issue of Cancer Cell, DeNardo and colleagues demonstrate that IL-4-producing T cells enhance metastasis by programming macrophages to produce factors that enhance tumor invasion.
尽管内源性T细胞在抗肿瘤免疫中的作用仍存在争议，但对于T细胞是否以及如何促进肿瘤发生却知之甚少。在本期《癌细胞》杂志中，德纳多及其同事证明，产生白细胞介素-4的T细胞通过促使巨噬细胞产生增强肿瘤侵袭的因子来促进转移。
