Haraldsson H Magnus, Ettinger Ulrich, Magnusdottir Brynja B, Sigmundsson Thordur, Sigurdsson Engilbert, Ingason Andres, Petursson Hannes
Division of Psychiatry, Landspitali-University Hospital, Reykjavik, Iceland.
Psychiatry Res. 2009 Sep 30;169(2):173-5. doi: 10.1016/j.psychres.2008.10.003. Epub 2009 Jul 31.
The association between the catechol-O-methyltransferase (COMT) val(158)met polymorphism (rs4680) and smooth pursuit eye movements (SPEM) was investigated in 110 schizophrenia patients and 96 controls. Patients had lower steady-state pursuit gain and made more frequent saccades than controls. Genotype was not associated with schizophrenia or SPEM, in either group or the combined sample. SPEM deficits in schizophrenia appear to be determined by genotypes other than rs4680, although the study may have lacked power to detect small effects.
在110例精神分裂症患者和96名对照者中研究了儿茶酚-O-甲基转移酶（COMT）val（158）met多态性（rs4680）与平稳跟踪眼球运动（SPEM）之间的关联。患者的稳态跟踪增益较低，比对照者产生更多的扫视。在任何一组或合并样本中，基因型均与精神分裂症或SPEM无关。精神分裂症患者的SPEM缺陷似乎由rs4680以外的基因型决定，尽管该研究可能缺乏检测微小效应的效力。
