Le Tourneau A, Audouin J, Diebold J, Pujade-Lauraine E, Bernadou A
Service Central Jacques Delarue d'Anatomie et de Cytologie Pathologiques, Hôtel-Dieu, Paris, France.
Pathol Res Pract. 1990 Dec;186(6):784-92; discussion 792-4. doi: 10.1016/S0344-0338(11)80270-0.
Unusual intracytoplasmic inclusions are occasionally seen in some variants of malignant lymphoma. We report here a case of large anaplastic cell malignant lymphoma with peculiar vacuoles of probable endocytotic origin. Immunological findings demonstrated the characteristics of activated cells typical of a large anaplastic cell Ki-1 positive lymphoma. The tumour cells exhibited a phenotype of peripheral helper-inducer T-cells. The intracytoplasmic vacuoles were positive with the T surface marker antibodies. Ultrastructurally, these inclusions were closely related to the microvesicle-containing vacuoles reported in signet ring cell lymphomas of B or T cell lineage. The mechanism of cytoplasmic vacuole formation is discussed. An endocytotic origin is possible. The resemblance to the "capping" phenomenon in small lymphocytes is stressed.
在某些恶性淋巴瘤变体中偶尔可见异常的胞质内包涵体。我们在此报告一例伴有可能源自内吞作用的特殊空泡的大细胞间变性恶性淋巴瘤。免疫组化结果显示出典型的大细胞间变性Ki-1阳性淋巴瘤活化细胞的特征。肿瘤细胞表现出外周辅助诱导性T细胞的表型。胞质内空泡对T表面标志物抗体呈阳性。超微结构上，这些包涵体与B或T细胞系印戒细胞淋巴瘤中报道的含微泡的空泡密切相关。本文讨论了细胞质空泡形成的机制。内吞作用起源是有可能的。强调了与小淋巴细胞中“帽化”现象的相似性。
