Ferrante E, Savino A
Divisione di Neurologia, Ospedale San Michele, Cagliari.
Riv Neurol. 1990 May-Jun;60(3):131-6.
A longitudinal clinical-electrophysiological study has been carried out on 6 leukaemic children during the treatment with vincristine. The Authors emphasize: 1) in the vincristine neuropathy the motor and sensitive fibres are initially affected in the distal segments with subsequent centripetal discussion, this agrees with the neuropathological picture characterized by distal axonal degeneration with processes dying-back type; 2) there is a relationship between dose-duration of the treatment and neurotoxic effects.
对6名白血病儿童在接受长春新碱治疗期间进行了一项纵向临床电生理研究。作者强调：1）在长春新碱所致神经病变中，运动和感觉纤维最初在远端节段受累，随后向心性扩展，这与以远端轴索性变性伴逆行性改变为特征的神经病理学表现相符；2）治疗的剂量-持续时间与神经毒性作用之间存在关联。
