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小肠镜检查在克罗恩病诊断和治疗中的应用

Enteroscopy in the diagnosis and management of Crohn disease.

作者信息

Pasha Shabana F, Leighton Jonathan A

机构信息

Division of Gastroenterology and Hepatology, Department of Internal Medicine, Mayo Clinic, Scottsdale, AZ 85259, USA.

出版信息

Gastrointest Endosc Clin N Am. 2009 Jul;19(3):427-44. doi: 10.1016/j.giec.2009.04.004.

Abstract

Crohn disease is a chronic disorder that can affect any part of the gastrointestinal tract, and is characterized by mucosal and transmural inflammation of the bowel wall. The disease most commonly involves the small bowel. Evaluation of patients with suspected Crohn disease has traditionally involved the use of ileocolonoscopy, push enteroscopy, and barium small bowel radiography. A large proportion of patients with mild small bowel disease or involvement of the mid small bowel can potentially be missed if only these tests are utilized. Enteroscopy is defined as direct visualization of the small bowel using a fiber optic or wireless endoscope. Following recent advances in technology, enteroscopy currently plays a pivotal role not only in the diagnosis of small bowel Crohn disease but also in the management of its complications, such as bleeding and strictures. Enteroscopy may have additional roles in the future, including the objective assessment of mucosal response to therapy, and surveillance for small bowel malignancy. This article focuses on the utility of enteroscopy, and its advantages and limitations in the evaluation and longterm management of Crohn disease.

摘要

克罗恩病是一种可累及胃肠道任何部位的慢性疾病,其特征为肠壁的黏膜和透壁性炎症。该病最常累及小肠。传统上,对疑似克罗恩病患者的评估包括使用回结肠镜检查、推进式小肠镜检查和小肠钡剂造影。如果仅采用这些检查,很大一部分轻度小肠疾病患者或小肠中段受累患者可能会被漏诊。小肠镜检查是指使用纤维内镜或无线内镜直接观察小肠。随着技术的最新进展,小肠镜检查目前不仅在小肠克罗恩病的诊断中发挥关键作用,而且在其并发症(如出血和狭窄)的管理中也发挥关键作用。小肠镜检查未来可能还有其他作用,包括对黏膜治疗反应的客观评估以及小肠恶性肿瘤的监测。本文重点关注小肠镜检查的效用及其在克罗恩病评估和长期管理中的优缺点。

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