Li Fujun, Zou Yiyou, Huang Tianhui
Department of Gastroenterology, Xiangya Hospital,Central South Uinversity, Changsha 410008, China.
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2009 Jul;34(7):599-602.
To determine the effect of prokinetic agents such as domperidone, mosapride, clarithromycin, and itopride on the electrical activity of the stomach and duodenum in SD rats,and also to explore the mechanism.
The organism functional experiment system BL-420E was used to record the myoelectrical activity in the stomach and duodenum of SD rats in all groups using domperidone, mosapride, itopride, clarithromycin, and physiological saline on the interdigestive phase. The effect of the prokinetic agents on the amplitude and frequency of gastric and duodenal electromyogram in the SD rats was compared. The antagonists such as atropine, phentolamine, and propranolol were added to investigate the mechanism of action with all prokinetic agents.
All prokinetic agents increased the amplitude and frequency of gastric and duodenal fast waves in the SD rats(P<0.05). The effect of itopride was the most obvious among the 3 groups (P<0.05),and clarithromycin had the weakest effect(P<0.05). The amplitude and frequency of gastric and duodenal fast waves in the SD rats in the groups of clarithromycin,domperidone,mosapride, itopride, and physiological saline were inhibited by atropine(P<0.05),but not by phentolamine and propranolol.
Itopride, mosapride, domperidone, and clarithromycin can increase the amplitude and frequency of gastric and duodenal fast waves in the SD rats. The mechanism may be related to cholinergic receptors, but not adrenergic receptors.
探讨多潘立酮、莫沙必利、克拉霉素、伊托必利等促动力药物对SD大鼠胃和十二指肠电活动的影响，并探讨其作用机制。
采用生物机能实验系统BL-420E，记录各实验组SD大鼠在消化间期，分别给予多潘立酮、莫沙必利、伊托必利、克拉霉素及生理盐水后胃和十二指肠的肌电活动。比较各促动力药物对SD大鼠胃和十二指肠肌电图波幅和频率的影响。加入阿托品、酚妥拉明、普萘洛尔等拮抗剂，研究各促动力药物的作用机制。
各促动力药物均能增加SD大鼠胃和十二指肠快波的波幅和频率（P<0.05）。伊托必利组作用最明显（P<0.05），克拉霉素组作用最弱（P<0.05）。阿托品可抑制克拉霉素、多潘立酮、莫沙必利、伊托必利组及生理盐水组SD大鼠胃和十二指肠快波的波幅和频率（P<0.05），酚妥拉明和普萘洛尔无此作用。
伊托必利、莫沙必利、多潘立酮及克拉霉素可增加SD大鼠胃和十二指肠快波的波幅和频率。其机制可能与胆碱能受体有关，而与肾上腺素能受体无关。
