Erkurt Mehmet Ali, Aydogdu Ismet, Kuku Irfan, Kaya Emin, Basaran Yalcin
Department of Hematology,Faculty of Medicine, Inonu University, Malatya, Turkey.
Med Princ Pract. 2009;18(5):399-406. doi: 10.1159/000226295. Epub 2009 Jul 31.
The objective of this retrospective study was to report the clinicopathological data and the treatment outcomes in patients with primary gastrointestinal non-Hodgkin's lymphoma.
We carried out a retrospective analysis of 41 patients (22 females, 18 males, median age 58 and range 18-90 years) who presented to our department with histopathological diagnosis of primary gastrointestinal non-Hodgkin's lymphoma between 1995 and 2004.
The stomach was the most common extranodal site and was seen in 25 of 41 (61%) patients. At presentation 28 (68.3%) patients had gastrointestinal symptoms while 27 (65.9%) had B symptoms. The range of follow-up was 2-84 months with a median of 9 months. The overall survival rate was 3 years for 25 (61.2%) patients. The 3-year overall survival rate was better in patients with early-stage disease (stages I and II(1)) who were treated with surgery plus chemotherapy and/or radiation therapy than in those treated with chemotherapy alone (91.6 vs. 50%, p < 0.05). The disease had a significant impact on both the progression-free survival and overall survival rates.
Our data showed that surgical resection prior to postoperative chemotherapy was a better option for patients with early-stage disease with better patient survival.
本回顾性研究的目的是报告原发性胃肠道非霍奇金淋巴瘤患者的临床病理数据及治疗结果。
我们对1995年至2004年间因原发性胃肠道非霍奇金淋巴瘤组织病理学诊断而就诊于我科的41例患者（22例女性，18例男性，中位年龄58岁，年龄范围18 - 90岁）进行了回顾性分析。
胃是最常见的结外部位，41例患者中有25例（61%）出现。就诊时，28例（68.3%）患者有胃肠道症状，27例（65.9%）有B症状。随访时间为2 - 84个月，中位时间为9个月。25例（61.2%）患者的总生存率为3年。接受手术加化疗和/或放疗的早期疾病（Ⅰ期和Ⅱ(1)期）患者的3年总生存率优于单纯接受化疗的患者（91.6%对50%，p < 0.05）。该疾病对无进展生存率和总生存率均有显著影响。
我们的数据表明，对于早期疾病患者，术后化疗前行手术切除是更好的选择，患者生存率更高。
