Zhang Yan-hui, Sun Qin-feng, Yang Pi-shan
Department of Periodontology, School of Stomatology, Shangdong University, Jinan 250012, Shangdong Province, China.
Shanghai Kou Qiang Yi Xue. 2009 Jun;18(3):329-32.
Phenytoin is widely used as an antiepileptic drug in clinic, but a common and well-known adverse effect of its administration is gingival overgrowth which may influence the aesthetics and function of the oral cavity. The pathogenesis of phenytoin-induced gingival overgrowth is not very clear now. This review summarized the influences of phenytoin on gingival fibroblast,collagen homeostasis and some cytokines, etc.
苯妥英钠在临床上广泛用作抗癫痫药物，但其给药常见且众所周知的不良反应是牙龈增生，这可能会影响口腔的美观和功能。目前苯妥英钠所致牙龈增生的发病机制尚不完全清楚。本文综述了苯妥英钠对牙龈成纤维细胞、胶原稳态及某些细胞因子等的影响。
