Division of Sleep Medicine, Brigham and Women's Hospital, 221 Longwood Avenue BLI 438, Boston, MA 02115, USA.
Cancer Causes Control. 2009 Nov;20(9):1753-6. doi: 10.1007/s10552-009-9405-0. Epub 2009 Aug 1.
Observational data, though sparse and based on small studies with limited ability to control for known breast cancer risk factors, support a lower risk of breast cancer in blind women compared to sighted women. Mechanisms influenced by ocular light perception, such as melatonin or circadian synchronization, are thought to account for this lower risk.
To evaluate whether blind women with no perception of light (NPL) have a lower prevalence of breast cancer compared to blind women with light perception (LP), we surveyed a cohort of 1,392 blind women living in North America (66 breast cancer cases).
In multivariate-logistic regression models controlling for breast cancer risk factors, women with NPL had a significantly lower prevalence of breast cancer than women with LP (odds ratio, 0.43; 95% confidence interval, 0.21-0.85). We observed little difference in these associations when restricting to postmenopausal women, non-shift workers or when excluding women diagnosed with breast cancer within 2 or 4 years of onset of blindness. Blind women with NPL appear to have a lower risk of breast cancer, compared to blind women with LP. More research is needed to elucidate the impact of LP on circadian coordination and melatonin production in the blind and how these factors may relate to breast cancer risk.
观察性数据尽管稀疏，且基于小样本研究，对已知乳腺癌风险因素的控制能力有限，但仍支持盲女性患乳腺癌的风险低于视力正常女性。受光感影响的机制，如褪黑素或昼夜节律同步，被认为是导致这种低风险的原因。
为了评估无光感（NPL）的盲女性与有光感（LP）的盲女性相比，乳腺癌的患病率是否较低，我们调查了居住在北美的 1392 名盲女性队列（66 例乳腺癌病例）。
在控制乳腺癌风险因素的多变量逻辑回归模型中，NPL 女性的乳腺癌患病率明显低于 LP 女性（比值比，0.43；95%置信区间，0.21-0.85）。当限制在绝经后女性、非轮班工人或排除失明后 2 或 4 年内诊断为乳腺癌的女性时，这些关联几乎没有差异。与 LP 女性相比，NPL 女性患乳腺癌的风险似乎较低。需要进一步研究来阐明 LP 对盲人群昼夜协调和褪黑素产生的影响，以及这些因素如何与乳腺癌风险相关。
