Department of Neuroscience, Rockefeller Neuroscience Institute, West Virginia University, Morgantown, WV 26506, USA.
Department of Medicine, Division of Oncology/Hematology, West Virginia University, Morgantown, WV 26506, USA.
Int J Mol Sci. 2020 Dec 8;21(24):9360. doi: 10.3390/ijms21249360.
For many individuals in industrialized nations, the widespread adoption of electric lighting has dramatically affected the circadian organization of physiology and behavior. Although initially assumed to be innocuous, exposure to artificial light at night (ALAN) is associated with several disorders, including increased incidence of cancer, metabolic disorders, and mood disorders. Within this review, we present a brief overview of the molecular circadian clock system and the importance of maintaining fidelity to bright days and dark nights. We describe the interrelation between core clock genes and the cell cycle, as well as the contribution of clock genes to oncogenesis. Next, we review the clinical implications of disrupted circadian rhythms on cancer, followed by a section on the foundational science literature on the effects of light at night and cancer. Finally, we provide some strategies for mitigation of disrupted circadian rhythms to improve health.
对于工业化国家的许多人来说，电灯的广泛采用极大地影响了生理和行为的昼夜节律组织。尽管最初认为无害，但夜间人工光照（ALAN）与几种疾病有关，包括癌症、代谢紊乱和情绪障碍的发病率增加。在这篇综述中，我们简要概述了分子昼夜节律钟系统以及保持对明亮白天和黑暗夜晚的保真度的重要性。我们描述了核心时钟基因与细胞周期之间的相互关系，以及时钟基因对致癌作用的贡献。接下来，我们回顾了昼夜节律紊乱对癌症的临床影响，然后是关于夜间光照和癌症影响的基础科学文献的部分。最后，我们提供了一些减轻昼夜节律紊乱以改善健康的策略。
