Nuss J M, Renhowe P A
Chiron Corporation, Emeryville, CA 94608, USA.
Curr Opin Drug Discov Devel. 1999 Nov;2(6):631-50.
Combinatorial chemistry is now regarded as an important component of the drug discovery process and is increasingly having an impact in other areas of the chemical sciences, such as catalysis and materials science. Solid-supported organic synthesis continues to be an integral component in the efficient assembly of combinatorial libraries. This review attempts to describe some of the most important recent developments in solid-supported organic synthesis during the period 1998 to 1999. Particular emphasis is placed on the development of novel, efficient methods for the synthesis of diverse, non-oligomeric libraries and structurally complex molecules.
组合化学如今被视为药物发现过程的一个重要组成部分，并且在化学科学的其他领域，如催化和材料科学中也日益产生影响。固相支持的有机合成仍然是组合库高效组装中不可或缺的组成部分。本综述试图描述1998年至1999年期间固相支持有机合成的一些最重要的最新进展。特别强调了用于合成多样的、非寡聚库和结构复杂分子的新颖、高效方法的开发。
