Piotrovsky V K
Janssen Research Foundation, Turnhoutseweg 30, 2340 Beerse, Belgium.
Curr Opin Drug Discov Devel. 2000 May;3(3):314-30.
Pharmacokinetics (PK) and pharmacodynamics (PD) are two scientific disciplines forming the basis of modern pharmaco- and chemotherapy. PK reflects what the body does to drugs and primarily deals with plasma concentration of drugs, whereas PD reflects what drugs do to the body, focusing on time-courses of responses produced by drugs. PK-PD modeling is a mathematical tool, which is used to establish a quantitative relationship between PK and PD. Population PK and PD modeling is aimed to quantify inter- and intra-individual variability in drug concentrations and responses, respectively. This review will attempt to summarize the progress in population PK and PD modeling over the last five years. Mixed-effects modeling is a statistical tool which makes population PK-PD analysis feasible, and this review sheds some light on basic ideas and applications of this powerful method without using complicated mathematics and statistics. Major concepts, approaches and methods are introduced on the basis of simplified examples that make these understandable for readers not involved in PK-PD modeling.
药代动力学（PK）和药效动力学（PD）是构成现代药物治疗和化疗基础的两个科学学科。PK反映机体对药物的作用，主要涉及药物的血浆浓度，而PD反映药物对机体的作用，关注药物产生的反应的时间进程。PK-PD建模是一种数学工具，用于建立PK和PD之间的定量关系。群体PK和PD建模旨在分别量化个体间和个体内药物浓度及反应的变异性。本综述将尝试总结过去五年群体PK和PD建模的进展。混合效应建模是一种使群体PK-PD分析可行的统计工具，本综述在不使用复杂数学和统计学的情况下，阐明了这种强大方法的基本思想和应用。基于简化示例介绍主要概念、方法和手段，以使未参与PK-PD建模的读者能够理解。
