Chen Kevin X, Njoroge F George
Schering-Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA.
Curr Opin Investig Drugs. 2009 Aug;10(8):821-37.
HCV NS3 serine protease mediates the cleavage of the HCV polyprotein to release the functional proteins that are essential for viral propagation. The inhibition of NS3 protease activity is expected to block HCV replication in infected host cells, and therefore protease inhibitors are a potential new treatment strategy for HCV. Several novel HCV protease inhibitors have been discovered, of which some have been clinically proven to be effective in achieving sustained virological response in patients with HCV genotype 1 at rates higher than those observed with the standard of care. This review focuses on the recent advances in the development of HCV protease inhibitors.
丙型肝炎病毒（HCV）NS3丝氨酸蛋白酶介导HCV多聚蛋白的切割，以释放对病毒传播至关重要的功能蛋白。抑制NS3蛋白酶活性有望阻断HCV在受感染宿主细胞中的复制，因此蛋白酶抑制剂是一种潜在的HCV新治疗策略。已经发现了几种新型HCV蛋白酶抑制剂，其中一些已在临床上被证明能有效使HCV 1型患者实现持续病毒学应答，其比率高于标准治疗观察到的比率。本综述重点关注HCV蛋白酶抑制剂开发的最新进展。
