Miao C Y, Gu K M
Department of Pharmacology, Second Military Medical University, Shanghai, China.
Zhongguo Yao Li Xue Bao. 1990 May;11(3):217-20.
The effect of sulmazole (Sul) on beating rate of cultured neonatal rat cardiomyocytes was similar to that of isoproterenol (Iso). They all produced a positive chronotropic action in a dose-dependent manner (Sul 1-100 mumol/L, Iso 1-300 nmol/L). Iso increased intracellular cAMP levels in a dose-dependent manner simultaneously, while Sul did not until toxic concentration (1 mmol/L) was given. With Sul 300 mumol/L the cAMP levels were not elevated significantly even when the positive chronotropic effect was maximal (5 min). The results indicate that cAMP is not important in mediating the positive chronotropic effect of Sul.
舒马唑（Sul）对培养的新生大鼠心肌细胞搏动率的影响与异丙肾上腺素（Iso）相似。它们均以剂量依赖性方式产生正性变时作用（Sul 1 - 100 μmol/L，Iso 1 - 300 nmol/L）。Iso同时以剂量依赖性方式增加细胞内cAMP水平，而Sul直到给予毒性浓度（1 mmol/L）时才会增加。给予300 μmol/L的Sul时，即使正性变时作用达到最大（5分钟），cAMP水平也未显著升高。结果表明，cAMP在介导Sul的正性变时作用中并不重要。
