Department of Biological Sciences, University of Maryland Baltimore County, Baltimore, Maryland 21250, USA.
Mol Reprod Dev. 2009 Oct;76(10):954-65. doi: 10.1002/mrd.21085.
The central nervous system of vertebrate embryos originates from the neural tube (NT), a simple epithelium surrounding a central lumen. The mechanisms underlying the shaping of the NT, a process otherwise known as neurulation, have been the focus of numerous studies, using a variety of model systems. Yet, it remains unclear to what extent neurulation is conserved across vertebrates. This review provides a comparison between modes of neurulation, with a focus on cellular mechanisms. An emerging concept is that cell behaviors reveal similarities between modes of neurulation that cannot be predicted from morphological comparisons.
脊椎动物胚胎的中枢神经系统来源于神经管（NT），这是一种环绕中央腔的简单上皮。神经管成形的机制，即神经胚形成，一直是许多研究的焦点，使用了多种模型系统。然而，神经管形成在脊椎动物中究竟在多大程度上保守仍然不清楚。本综述比较了神经胚形成的模式，重点是细胞机制。一个新兴的概念是，细胞行为揭示了神经胚形成模式之间的相似性，而这些相似性无法从形态学比较中预测。
