Jacobsson Susanne, Mölling Paula, Olcén Per
National Reference Laboratory for Pathogenic Neisseria, Department of Laboratory Medicine, Clinical Microbiology, Orebro University Hospital, SE-701 85 Orebro, Sweden.
Vaccine. 2009 Sep 25;27(42):5755-9. doi: 10.1016/j.vaccine.2009.07.056. Epub 2009 Aug 3.
The IgG antibody levels directed against fHbp and NadA, two potential vaccine antigens for Neisseria meningitidis, were examined in order to investigate the extent of natural immunisation against these antigens in different age groups. As a comparison, the IgG antibody levels against Haemophilus influenzae type b were examined. In the two youngest age groups, below 10 years of age, relatively low levels of both anti-fHbp and anti-NadA were measured. A 15-fold higher geometric mean concentration of anti-fHbp was noted in the age group 20-29 years as compared to the age group 15-19 years. The peak concentration was found at 30-39 years, followed by decreased levels with age. Anti-NadA showed a certain increase up to 9 years followed by an even increase up to 40-49 years.
为了研究不同年龄组针对脑膜炎奈瑟菌两种潜在疫苗抗原fHbp和NadA的自然免疫程度，检测了针对这两种抗原的IgG抗体水平。作为比较，还检测了针对b型流感嗜血杆菌的IgG抗体水平。在两个最年幼的年龄组（10岁以下）中，检测到的抗fHbp和抗NadA水平相对较低。与15 - 19岁年龄组相比，20 - 29岁年龄组的抗fHbp几何平均浓度高15倍。峰值浓度出现在30 - 39岁，随后随年龄增长而下降。抗NadA在9岁前有一定升高，随后在40 - 49岁时进一步升高。
