Veĭnberg G A, Gol'dberg Iu Sh, Belevich E M, Akif'ev O N
Antibiotiki. 1977 Jun;22(6):495-8.
Derivatographic analysis of 5 samples of 6-beta-(hexahydro-IH-azepin-I-yl)methylenamino penicillanic acid was performed. In addition to the antibiotic the samples had water and acetone in their composition. No effects associated with changes in the physical and chemical state of the substance were observed on the derivatogramme of the samples containing 0.2 and 0.8 per cent of water up 140 degrees C. With a further increase in the temperature an exothermic effect was observed with maximum at 152--153 degrees C connected with melting and chemical degradation of the substance. The derivatogrammes of the samples containing 89--96.4 per cent of the antibiotic were characterized by an endothermic effect with minimum at 65 degrees C caused by evaporation of acetone and partially water from them and by an exothermic effect with maximum at 120 degrees C practically not accompanied by any change in the weight resulting from chemical interaction of the antibiotic with water. The study showed sensitivity of 6-beta-(hexahydro-IH-azepin-I-yl)methylenaminopenicillanic acid to the presence of even insignificant amounts of water in it, maximum elimination of which from the antibiotic is an important factor of increasing its stability.
对5个6-β-(六氢-1H-氮杂环庚烷-1-基)亚甲基氨基青霉烷酸样品进行了导数热重分析。除抗生素外，样品成分中还含有水和丙酮。在140℃以下，含0.2%和0.8%水的样品的导数热重图上未观察到与物质物理和化学状态变化相关的影响。随着温度进一步升高，观察到放热效应，最大值出现在152 - 153℃，这与物质的熔化和化学降解有关。含89 - 96.4%抗生素的样品的导数热重图的特征是：由于丙酮和部分水的蒸发，在65℃出现吸热效应且为最小值；在120℃出现放热效应且为最大值，这实际上并未伴随抗生素与水的化学相互作用导致的重量变化。研究表明，6-β-(六氢-1H-氮杂环庚烷-1-基)亚甲基氨基青霉烷酸对其中即使微量水的存在也很敏感，从抗生素中最大程度地除去水是提高其稳定性的一个重要因素。
