Keller E A, Molina V A, Orsingher O A
Departamento de Farmacología, Facultad de Ciencias Químicas Universidad Naçional de Córdoba, Argentina.
Pharmacol Biochem Behav. 1990 Dec;37(4):675-8. doi: 10.1016/0091-3057(90)90545-s.
Reactivity of presynaptic dopaminergic and alpha 2-adrenoceptors following repeated stress or desipramine treatment was investigated by means of apomorphine (APO)- or clonidine (CLO)-induced hypoactivity, respectively, in adult rats undernourished at perinatal age. Under basal conditions, a comparable hypoactive response was observed in control and experimental animals following either APO or CLO administration. Chronic DMI or repeated immobilization sessions attenuated the hypoactivity elicited by APO or CLO in control animals; however, this effect was not observed in experimental rats. These findings demonstrate that deprived animals show impairment to produce neuronal adaptive changes in response to appropriate stimuli, which may account for the behavioral alterations attributed to early undernutrition.
通过阿扑吗啡（APO）或可乐定（CLO）诱导的活动减退，分别研究围产期营养不良的成年大鼠在反复应激或地昔帕明治疗后突触前多巴胺能和α2-肾上腺素能受体的反应性。在基础条件下，给予APO或CLO后，对照动物和实验动物均观察到类似的活动减退反应。慢性地昔帕明（DMI）或反复固定应激会减弱对照动物中APO或CLO诱导的活动减退；然而，在实验大鼠中未观察到这种效应。这些发现表明，营养缺乏的动物在对适当刺激作出反应时，产生神经元适应性变化的能力受损，这可能解释了早期营养不良所致的行为改变。
