Sato T, Koseki S, Takahashi S, Maie O
Department of Dermatology, Akita University School of Medicine, Japan.
Mycoses. 1990 Sep-Oct;33(9-10):455-63. doi: 10.1111/myc.1990.33.9-10.455.
A case of localized cutaneous cryptococcosis successfully treated with oral itraconazole is reported. The patient, a 63-year-old Japanese housewife, had had an erythematous and partly eroded lesion in the area of her right earlobe for about 10 months. No findings suggesting a primary focus of Cryptococcus infection were found in the lung, central nervous system or other internal organs. The isolate obtained from the lesion was identified as Cryptococcus neoformans based on the demonstration of encapsulated blastospores and its biological characteristics. The clinical course shifted toward healing in parallel with a decreased serum level of anticryptococcal antibody after initiation of treatment with oral itraconazole in a dose of 100 mg once daily. The treatment was discontinued after 13 weeks. There were neither subjective nor objective side effects. Furthermore, this paper reviews the medications employed in 18 cases with cutaneous cryptococcosis reported in Japan during the nearly 40-year period between 1952 and 1989.
报告了1例口服伊曲康唑成功治疗的局限性皮肤隐球菌病病例。患者为一名63岁的日本家庭主妇，其右耳垂部位出现红斑且部分糜烂的皮损约10个月。在肺部、中枢神经系统或其他内脏器官未发现提示隐球菌感染原发灶的迹象。从皮损处分离得到的菌株，根据其荚膜芽生孢子的表现及其生物学特性，被鉴定为新型隐球菌。口服伊曲康唑，剂量为每日1次，每次100mg，治疗开始后，随着血清抗隐球菌抗体水平下降，临床病程逐渐好转。13周后停药。未出现主观及客观的副作用。此外，本文还回顾了1952年至1989年近40年间日本报道的18例皮肤隐球菌病所使用的药物。
