Steplewski Z, Kilarski W, Grabska A
Arch Immunol Ther Exp (Warsz). 1977;25(3):331-9.
A comparison of four mouse tumorigenic cell lines derived from transformed peritoneal macrophages is reported. Tumorigenicity of various cell concentration inocula was compared with their saturation densities, agglutinability by Con A, and their surface morphologies as revealed by SEM. It is shown that increase in tumorigenicity after repeated passage through syngeneic mice is associated with changes in their growth characteristics, Con A agglutinability, and correlates with surface changes observed by SEM. The results show that after repeated transfer of transformed cells in syngeneic mice the cells become more tumorigenic, have a higher degree of agglutinability, and show progressive changes of their surface morphology.
本文报道了四种源自转化腹膜巨噬细胞的小鼠致瘤细胞系的比较。将不同细胞浓度接种物的致瘤性与其饱和密度、刀豆蛋白A（Con A）的凝集性以及扫描电子显微镜（SEM）显示的表面形态进行了比较。结果表明，在同基因小鼠中反复传代后致瘤性的增加与其生长特性、Con A凝集性的变化相关，并且与SEM观察到的表面变化相关。结果显示，在同基因小鼠中反复传代转化细胞后，细胞的致瘤性更强、凝集性更高，并且其表面形态呈现渐进性变化。
