Linking amyloid and tau pathology in Alzheimer's disease: the role of membrane cholesterol in Abeta-mediated tau toxicity.
作者信息
Wray Selina, Noble Wendy
机构信息
Department of Molecular Neuroscience, UCL Institute of Neurology, London WC1N 3BG, United Kingdom.
出版信息
J Neurosci. 2009 Aug 5;29(31):9665-7. doi: 10.1523/JNEUROSCI.2234-09.2009.
Abstract
摘要
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本文引用的文献
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Increased membrane cholesterol might render mature hippocampal neurons more susceptible to beta-amyloid-induced calpain activation and tau toxicity.膜胆固醇增加可能使成熟海马神经元更容易受到β-淀粉样蛋白诱导的钙蛋白酶激活和tau蛋白毒性的影响。
J Neurosci. 2009 Apr 8;29(14):4640-51. doi: 10.1523/JNEUROSCI.0862-09.2009.
2
Tau phosphorylation: the therapeutic challenge for neurodegenerative disease.tau蛋白磷酸化：神经退行性疾病的治疗挑战
Trends Mol Med. 2009 Mar;15(3):112-9. doi: 10.1016/j.molmed.2009.01.003. Epub 2009 Feb 24.
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Cellular prion protein mediates impairment of synaptic plasticity by amyloid-beta oligomers.细胞朊蛋白介导β-淀粉样寡聚体对突触可塑性的损害。
Nature. 2009 Feb 26;457(7233):1128-32. doi: 10.1038/nature07761.
4
Amyloid-beta peptide (Abeta) neurotoxicity is modulated by the rate of peptide aggregation: Abeta dimers and trimers correlate with neurotoxicity.β-淀粉样肽（Aβ）的神经毒性受肽聚集速率的调节：Aβ二聚体和三聚体与神经毒性相关。
J Neurosci. 2008 Nov 12;28(46):11950-8. doi: 10.1523/JNEUROSCI.3916-08.2008.
5
Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer's disease mouse model.在阿尔茨海默病小鼠模型中，减少内源性tau可改善β淀粉样蛋白诱导的缺陷。
Science. 2007 May 4;316(5825):750-4. doi: 10.1126/science.1141736.
6
beta-Amyloid-induced dynamin 1 degradation is mediated by N-methyl-D-aspartate receptors in hippocampal neurons.β-淀粉样蛋白诱导的发动蛋白1降解由海马神经元中的N-甲基-D-天冬氨酸受体介导。
J Biol Chem. 2006 Sep 22;281(38):28079-89. doi: 10.1074/jbc.M605081200. Epub 2006 Jul 24.
7
Common structure and toxic function of amyloid oligomers implies a common mechanism of pathogenesis.淀粉样寡聚体的共同结构和毒性功能暗示了一种共同的发病机制。
Neurology. 2006 Jan 24;66(2 Suppl 1):S74-8. doi: 10.1212/01.wnl.0000192103.24796.42.
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The generation of a 17 kDa neurotoxic fragment: an alternative mechanism by which tau mediates beta-amyloid-induced neurodegeneration.17 kDa神经毒性片段的产生：tau蛋白介导β-淀粉样蛋白诱导神经退行性变的另一种机制。
J Neurosci. 2005 Jun 1;25(22):5365-75. doi: 10.1523/JNEUROSCI.1125-05.2005.
9
The role of caspase cleavage of tau in Alzheimer disease neuropathology.半胱天冬酶切割tau在阿尔茨海默病神经病理学中的作用。
J Neuropathol Exp Neurol. 2005 Feb;64(2):104-12. doi: 10.1093/jnen/64.2.104.
10
Differential sensitivity to proteolysis by brain calpain of adult human tau, fetal human tau and PHF-tau.
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