Kampa Kerstin M, Bonin Michael, Lopez Charles D
Medizinische Universitätsklinik, Department of Hematology, Oncology, Rheumatology, Immunology and Pulmology, Universität Tübingen, Tübingen, Germany.
Cell Cycle. 2009 Sep 15;8(18):2871-6. doi: 10.4161/cc.8.18.9474. Epub 2009 Sep 8.
Apoptosis Stimulating Protein of p53-2, ASPP2, aka 53BP2L, (encoded by TP53BP2) is a pro-apoptotic member of a family of p53 binding proteins. ASPP2 expression is frequently suppressed in human cancers and numerous studies have consistently demonstrated that ASPP2 inhibits cell growth as well as stimulates apoptosis-at least in part through a p53-mediated pathway. Two independent mouse models have shown that ASPP2 is a haplo-insufficient tumor suppressor and underscore the importance of the role of ASPP2 in human cancer. However, mounting evidence suggests that the mechanism(s) of action for ASPP2 are complex and likely extend beyond stimulation of apoptotic programs. Data highlighting this expanding spectrum of potential ASPP2-mediated pathways is summarized along with new results from recent in vivo models suggesting new avenues for investigation.
p53凋亡刺激蛋白2（ASPP2），又名53BP2L（由TP53BP2编码），是p53结合蛋白家族的一个促凋亡成员。ASPP2的表达在人类癌症中经常受到抑制，大量研究一致表明，ASPP2至少部分通过p53介导的途径抑制细胞生长并刺激细胞凋亡。两个独立的小鼠模型表明，ASPP2是一种单倍体不足的肿瘤抑制因子，并强调了ASPP2在人类癌症中作用的重要性。然而，越来越多的证据表明，ASPP2的作用机制很复杂，可能超出了对凋亡程序的刺激。本文总结了突出ASPP2介导的潜在途径不断扩大范围的数据，以及来自最近体内模型的新结果，这些结果提示了新的研究途径。
